Intravenous anesthetic, propofol inhibits invasion of cancer cells

Intravenous anesthetic, propofol (2,6-diisopropylphenol), is extensively used for general anesthesia without knowing the effects on cancer. We found here that clinically relevant concentrations of propofol (1–5 μg/ml) decreased the invasion ability of human cancer cells (HeLa, HT1080, HOS and RPMI-7...

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Bibliographic Details
Published in:Cancer letters 2002-10, Vol.184 (2), p.165-170
Main Authors: Mammoto, Tadanori, Mukai, Mutsuko, Mammoto, Akiko, Yamanaka, Yasutsugu, Hayashi, Yukio, Mashimo, Takashi, Kishi, Yoshihiko, Nakamura, Hiroyuki
Format: Article
Language:English
Subjects:
Actins - metabolism
Anesthesia
Anesthetic
Anesthetics, Intravenous - pharmacology
Animals
Antineoplastic agents
Behavior
Biological and medical sciences
Bone cancer
Bone Neoplasms - pathology
Cancer cells
Cell adhesion & migration
Cell Adhesion - drug effects
Cell culture
Chemotherapy
Cytoskeleton
HeLa Cells - drug effects
HeLa Cells - pathology
Humans
Invasion
Lung Neoplasms - prevention & control
Lung Neoplasms - secondary
Medical sciences
Metastasis
Mice
Neoplasm Invasiveness - prevention & control
Osteosarcoma - pathology
Osteosarcoma - prevention & control
Osteosarcoma - secondary
Pharmacology. Drug treatments
Plasma
Propofol
Propofol - pharmacology
Tumor Cells, Cultured
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Summary:Intravenous anesthetic, propofol (2,6-diisopropylphenol), is extensively used for general anesthesia without knowing the effects on cancer. We found here that clinically relevant concentrations of propofol (1–5 μg/ml) decreased the invasion ability of human cancer cells (HeLa, HT1080, HOS and RPMI-7951). In the HeLa cells treated with propofol, formation of actin stress fibers as well as focal adhesion were inhibited, and propofol had little effect on the invasion ability of the HeLa cells with active Rho A (Val 14-Rho A). In addition, continuous infusion of propofol inhibited pulmonary metastasis of murine osteosarcoma (LM 8) cells in mice. These results suggest that propofol inhibits the invasion ability of cancer cells by modulating Rho A and this agent might be an ideal anesthetic for cancer surgery.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(02)00210-0