Effects of a vitamin pool (vitamins A, E, and C) on the tissue necrosis process: Experimental study on rats

During surgical procedures on the epidermis, either aesthetic or reconstructive, the medical literature shows that certain technical standards and skin flap proportions should be followed, unless the risk of necrosis increases, in different degrees, directly related to the trauma. This study evaluat...

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Bibliographic Details
Published in:Aesthetic plastic surgery 2002-05, Vol.26 (3), p.197-202
Main Authors: PORTO DA ROCHA, Rogério, LUCIO, Daniela Pettinato, DE LIMA SOUZA, Thiago, PEREIRA, Sérgio Tavolaro, MEDEIROS FERNANDES, Geraldo José
Format: Article
Language:English
Subjects:
Animals
Ascorbic Acid - administration & dosage
Ascorbic Acid - pharmacology
Biological and medical sciences
General and cellular metabolism. Vitamins
Male
Medical sciences
Necrosis
Neovascularization, Physiologic - drug effects
Pharmacology. Drug treatments
Rats
Rats, Wistar
Skin plastic surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgical Flaps - pathology
Tropical medicine
Vitamin A - administration & dosage
Vitamin A - pharmacology
Vitamin E - administration & dosage
Vitamin E - pharmacology
Vitamins - administration & dosage
Vitamins - pharmacology
Wound Healing - drug effects
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Summary:During surgical procedures on the epidermis, either aesthetic or reconstructive, the medical literature shows that certain technical standards and skin flap proportions should be followed, unless the risk of necrosis increases, in different degrees, directly related to the trauma. This study evaluates the evolution of skin flaps on the dorsum of rats treated with a vitamin pool (VP) (vitamins A, E, and C). Twenty-six rats, divided into two groups, were used: (A) the treated group (13 specimens), in which we performed a dorsal skin flap and applied the VP, and (B) the control group (13 specimens), in which we performed a flap on the dorsum without application of the VP. Our results demonstrate that, at the macroscopic level, the group treated with the VP had more tissue sufferance, whereas at the microscopic level, small statistical differences were observed between the groups and also between the vertex and the middle of the flap. Despite these small differences, better results were obtained in group A, showing that in this study the clinical aspect did not correspond to the histological features.
ISSN:0364-216X
1432-5241
DOI:10.1007/s00266-002-1359-5