Alternative and aberrant splicing of MDM2 mRNA in human cancer

MDM2 has been characterized as a protein that binds to and facilitates degradation of the tumor suppressor p53. Interestingly, more than 40 different splice variants of MDM2 transcripts have been identified both in tumors and normal tissues, and the majority of these variants do not contain sequence...

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Bibliographic Details
Published in:Cancer Cell 2002-07, Vol.2 (1), p.9-15
Main Authors: Bartel, Frank, Taubert, Helge, Harris, Linda C
Format: Article
Language:English
Subjects:
Alternative Splicing
Animals
Binding Sites
Humans
Models, Genetic
Mutation
Neoplasm Proteins - genetics
Neoplasms - genetics
Neoplasms - pathology
Nuclear Proteins
Prognosis
Protein Isoforms - genetics
Protein Isoforms - metabolism
Proto-Oncogene Proteins - chemistry
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-mdm2
RNA, Messenger - genetics
RNA, Messenger - metabolism
Tumor Cells, Cultured
Tumor Suppressor Protein p53 - metabolism
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Summary:MDM2 has been characterized as a protein that binds to and facilitates degradation of the tumor suppressor p53. Interestingly, more than 40 different splice variants of MDM2 transcripts have been identified both in tumors and normal tissues, and the majority of these variants do not contain sequence encoding the p53 binding site. This review describes the different splice forms, the tissues in which they have been identified, and their association with tumor progression and prognosis. In addition, we discuss the potential functions of these variants and how they interact with full-length MDM2 protein.
ISSN:1535-6108
1878-3686
DOI:10.1016/S1535-6108(02)00091-0