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Alternative and aberrant splicing of MDM2 mRNA in human cancer
MDM2 has been characterized as a protein that binds to and facilitates degradation of the tumor suppressor p53. Interestingly, more than 40 different splice variants of MDM2 transcripts have been identified both in tumors and normal tissues, and the majority of these variants do not contain sequence...
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| Published in: | Cancer Cell 2002-07, Vol.2 (1), p.9-15 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c557t-4deea7f64f28b8a46205362cd9678a22ba3730ecc6b5cf87051f8c67d37869813 |
| container_end_page | 15 |
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| container_title | Cancer Cell |
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| creator | Bartel, Frank Taubert, Helge Harris, Linda C |
| description | MDM2 has been characterized as a protein that binds to and facilitates degradation of the tumor suppressor p53. Interestingly, more than 40 different splice variants of
MDM2 transcripts have been identified both in tumors and normal tissues, and the majority of these variants do not contain sequence encoding the p53 binding site. This review describes the different splice forms, the tissues in which they have been identified, and their association with tumor progression and prognosis. In addition, we discuss the potential functions of these variants and how they interact with full-length MDM2 protein. |
| doi_str_mv | 10.1016/S1535-6108(02)00091-0 |
| format | article |
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| identifier | ISSN: 1535-6108 |
| ispartof | Cancer Cell, 2002-07, Vol.2 (1), p.9-15 |
| issn | 1535-6108 1878-3686 |
| language | eng |
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| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Alternative Splicing Animals Binding Sites Humans Models, Genetic Mutation Neoplasm Proteins - genetics Neoplasms - genetics Neoplasms - pathology Nuclear Proteins Prognosis Protein Isoforms - genetics Protein Isoforms - metabolism Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 RNA, Messenger - genetics RNA, Messenger - metabolism Tumor Cells, Cultured Tumor Suppressor Protein p53 - metabolism |
| title | Alternative and aberrant splicing of MDM2 mRNA in human cancer |
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