Two new HLA-B alleles, B4422 and B4704, identified in a study of families with autoimmunity

: HLA‐B typing of approximately 1 262 individuals from a study of 372 simplex families with multiple sclerosis has led to the identification of two new alleles (HLA‐B*4422 and HLA‐B*4704). Sequencing confirmed that both of these new alleles represent novel combinations of previously described sequen...

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Bibliographic Details
Published in:Tissue antigens 2002-04, Vol.59 (4), p.338-340
Main Authors: Grams, S.E., Moonsamy, P.V., Mano, C., Oksenberg, J.R., Begovich, A.B.
Format: Article
Language:English
Subjects:
Alleles
Amino Acid Sequence
Autoimmunity - genetics
Base Sequence
Family Health
HLA class I
HLA-B
HLA-B Antigens - genetics
HLA-B44 Antigen
Humans
Molecular Sequence Data
multiple sclerosis
Multiple Sclerosis - genetics
polymorphism
Polymorphism, Genetic
sequence motif
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Summary:: HLA‐B typing of approximately 1 262 individuals from a study of 372 simplex families with multiple sclerosis has led to the identification of two new alleles (HLA‐B*4422 and HLA‐B*4704). Sequencing confirmed that both of these new alleles represent novel combinations of previously described sequence motifs, reinforcing the notion that recombination and/or gene conversion‐like events play an important role in generating HLA allelic diversity. The identification of these new alleles brings the total number of HLA‐B alleles to 465.
ISSN:0001-2815
1399-0039
DOI:10.1034/j.1399-0039.2002.590417.x