Low molecular weight PTP–IL‐4RA interaction in atopy predisposition

We recently described a protective effect of the low molecular weight protein tyrosine phosphatase (LMPTP) BC genotype, associated with the highest total enzymatic activity, against high serum IgE levels both in the English and the Italian populations. Here we test the hypothesis of a role of LMPTP...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2002-01, Vol.57 (s72), p.10-12
Main Authors: Bottini, N., Mao, X.‐Q., Borgiani, P., Saccucci, P., Stefanini, L., Greco, E., Fontana, L., Shirakawa, T., Hopkin, J. M.
Format: Article
Language:English
Subjects:
ACP1
Asthma - genetics
atopy
genetic interaction
Genetic Predisposition to Disease
Humans
Hypersensitivity, Immediate - genetics
IgE level
IL4RA
Immunoglobulin E - blood
Isoenzymes - genetics
LMPTP
Polymerase Chain Reaction
polymorphism
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Protein Tyrosine Phosphatases - genetics
Proto-Oncogene Proteins
Receptors, Interleukin-4 - genetics
Signal Transduction - genetics
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Summary:We recently described a protective effect of the low molecular weight protein tyrosine phosphatase (LMPTP) BC genotype, associated with the highest total enzymatic activity, against high serum IgE levels both in the English and the Italian populations. Here we test the hypothesis of a role of LMPTP in the negative modulation of IL‐4 signal transduction checking for genetic interaction between interleukin‐4 receptor alpha chain (IL‐4RA) genetic polymorphisms and LMPTP polymorphism in the predisposition to high total IgE levels in the English population. We find a significant interaction between LMPTP polymorphism and the intracellular Gln/Arg polymorphism in position 551 of IL‐4RA. Our data support the hypothesis of a direct or indirect biochemical interaction between LMPTP and IL‐4RA resulting in different modulation of IL‐4 signal transduction among joint genotypes.
ISSN:0105-4538
1398-9995
DOI:10.1034/j.1398-9995.57.s72.4.x