Evolutive peritoneal disease after conservative management and the use of infertility drugs in a patient with stage IIIC borderline micro‐papillary serous carcinoma (MPSC) of the ovary: Case report

A young nulliparous woman with stage IIIC bilateral borderline micro‐papillary serous carcinoma (MPSC) of the ovary underwent conservative surgery with optimal preservation of future fertility. The left ovary and a substantial portion of the right ovary were removed. The patient became pregnant at t...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2004-06, Vol.19 (6), p.1472-1475
Main Authors: Attar, Erkut, Berkman, Sinan, Topuz, Samet, Baysal, Bulent, Akhan, Suleyman, Chambers, Joseph T.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
borderline ovarian tumour/conservative surgery/fertility
Cesarean Section
Cystadenocarcinoma - pathology
Cystadenocarcinoma - surgery
Embryology: invertebrates and vertebrates. Teratology
Female
Fertility Agents, Female - therapeutic use
Fertilization in Vitro
Fundamental and applied biological sciences. Psychology
Humans
Hysterectomy
Neoplasm Invasiveness
Neoplasm Staging
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Ovariectomy - methods
Peritoneum - pathology
Pregnancy
Pregnancy Complications, Neoplastic
Reoperation
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Summary:A young nulliparous woman with stage IIIC bilateral borderline micro‐papillary serous carcinoma (MPSC) of the ovary underwent conservative surgery with optimal preservation of future fertility. The left ovary and a substantial portion of the right ovary were removed. The patient became pregnant at the first IVF cycle attempted after conservative management. A Cesarean section was performed in the 37th week of pregnancy and combined with very precise exploration; there were multiple non‐invasive implants on the peritoneal surface and liver, and contra‐lateral ovarian tissue was of normal appearance. Abdominal hysterectomy and right oophorectomy were done as a definitive treatment 3 months after the Caesarean section. The patient showed a rapid progression to invasive ovarian carcinoma in this period of time. MPSC has the greatest risk of malignant transformation among the advanced stage serous borderline tumours. Fertility‐sparing surgery is an option for young, childless women who would like to preserve their fertility. However, the treatment must be taken very cautiously and requires rigorous surveillance.
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/deh226