Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles

The following study examines the feasibility of nanoshell-assisted photo-thermal therapy (NAPT). This technique takes advantage of the strong near infrared (NIR) absorption of nanoshells, a new class of gold nanoparticles with tunable optical absorptivities that can undergo passive extravasation fro...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2004-06, Vol.209 (2), p.171-176
Main Authors: O'Neal, D.Patrick, Hirsch, Leon R., Halas, Naomi J., Payne, J.Donald, West, Jennifer L.
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Colonic Neoplasms - therapy
Confidence intervals
Feasibility Studies
Female
Gold
Gold - chemistry
Heat
Hyperthermia
Hyperthermia, Induced
Infrared Rays
Laser
Lasers
Light
Lymphatic system
Mice
Mice, Inbred BALB C
Mice, SCID
Microspheres
Minimally invasive therapy
Nanoshell
Nanotechnology
Near infrared
Phototherapy
Polyethylene Glycols - metabolism
Silicon - chemistry
Studies
Survival analysis
Survival Rate
Temperature
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The following study examines the feasibility of nanoshell-assisted photo-thermal therapy (NAPT). This technique takes advantage of the strong near infrared (NIR) absorption of nanoshells, a new class of gold nanoparticles with tunable optical absorptivities that can undergo passive extravasation from the abnormal tumor vasculature due to their nanoscale size. Tumors were grown in immune-competent mice by subcutaneous injection of murine colon carcinoma cells (CT26.WT). Polyethylene glycol (PEG) coated nanoshells (≈130 nm diameter) with peak optical absorption in the NIR were intravenously injected and allowed to circulate for 6 h. Tumors were then illuminated with a diode laser (808 nm, 4 W/cm 2, 3 min). All such treated tumors abated and treated mice appeared healthy and tumor free >90 days later. Control animals and additional sham-treatment animals (laser treatment without nanoshell injection) were euthanized when tumors grew to a predetermined size, which occurred 6–19 days post-treatment. This simple, non-invasive procedure shows great promise as a technique for selective photo-thermal tumor ablation.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2004.02.004