Metachronous bilateral mammary metaplastic and infiltrating duct carcinomas: A molecular study for clonality

Mammary metaplastic carcinoma is uncommon. In this study, both carcinoma and sarcoma components of a metaplastic carcinoma and a subsequent metachronous contralateral infiltrating ductal carcinoma were analyzed by microsatellite analysis for the loss of heterozygosity (LOH) patterns at multiple site...

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Bibliographic Details
Published in:Human pathology 2002-06, Vol.33 (6), p.677-679
Main Authors: Kung, Fred Y.L., Tse, Gary M.K., Lo, Kwok-Wai, Law, Bonita K.B., Chang, Alexander R., Chen, Meng-Hua
Format: Article
Language:English
Subjects:
Biological and medical sciences
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - genetics
Carcinoma, Ductal, Breast - pathology
carcinosarcoma
Chromosomes
Cloning, Molecular
Female
Gynecology. Andrology. Obstetrics
Humans
loss of heterozygosity
Loss of Heterozygosity - genetics
Mammary gland diseases
Medical sciences
metaplastic carcinoma
Middle Aged
Neoplasms, Second Primary - genetics
Neoplasms, Second Primary - pathology
Polymerase Chain Reaction
Sarcoma - pathology
Tumors
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Summary:Mammary metaplastic carcinoma is uncommon. In this study, both carcinoma and sarcoma components of a metaplastic carcinoma and a subsequent metachronous contralateral infiltrating ductal carcinoma were analyzed by microsatellite analysis for the loss of heterozygosity (LOH) patterns at multiple sites on chromosome arms 3p, 6q, 8, 9p, 11, 13q, 14q, 16q, and 17p. The LOH patterns between the carcinoma and sarcoma components in the first tumor were similar, indicating clonality. The LOH patterns between the first and second tumors were different at all chromosome arms, indicating different clonality and a second primary. We demonstrated a second primary carcinoma in a patient with previous metaplastic carcinoma rather than a metastasis with carcinoma component only. HUM PATHOL 33:677-679. Copyright 2002, Elsevier Science (USA). All rights reserved.
ISSN:0046-8177
1532-8392
DOI:10.1053/hupa.2002.124906