Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals

Background: The intake of 10 g/day of short-chain-fructo-oligosaccharides (sc-FOS) has been shown to increase significantly bifidus counts and to produce high amounts of short-chain fatty acids (SCFA), presumed to influence glucose and lipid metabolism. Aim: To evaluate the effects of moderate intak...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2004-06, Vol.23 (3), p.331-340
Main Authors: Giacco, R, Clemente, G, Luongo, D, Lasorella, G, Fiume, I, Brouns, F, Bornet, F, Patti, L, Cipriano, P, Rivellese, A.A, Riccardi, G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Glucose - metabolism
Colonic fermentation
Cross-Over Studies
Disorders of blood lipids. Hyperlipoproteinemia
Double-Blind Method
Fasting
Fatty Acids, Volatile - biosynthesis
Female
Fructo-oligosaccharides
Fructose - pharmacology
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - drug therapy
Hypercholesterolemia - metabolism
Hyperlypidaemia
Insulin - metabolism
Lipid Metabolism
Male
Medical sciences
Metabolic diseases
Middle Aged
Oligosaccharides - chemistry
Oligosaccharides - pharmacology
Postprandial Period
Triglycerides - metabolism
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Summary:Background: The intake of 10 g/day of short-chain-fructo-oligosaccharides (sc-FOS) has been shown to increase significantly bifidus counts and to produce high amounts of short-chain fatty acids (SCFA), presumed to influence glucose and lipid metabolism. Aim: To evaluate the effects of moderate intake of sc-FOS on glucose and lipid metabolism in individuals with mild hypercholesterolaemia. Design: A randomized double-blind sequential cross-over study. Subjects and methods: Thirty subjects of both genders (20 M/10 F), mean age 45.5±9.9 years ( M±SD), BMI 26.6±2.2 kg/m 2, with plasma cholesterol >5.17 and
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2003.07.010