Morinda lucida extract induces endothelium-dependent and -independent relaxation of rat aorta

The effect of an aqueous extract of Morinda lucida (ML) on vascular tone was tested using rat aortic rings precontracted with noradrenaline (10 −7 mol/l). Relaxation responses were determined with endothelium-intact, L-NAME-treated, methylene blue-treated and endothelium-denuded tissues. In the conc...

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Bibliographic Details
Published in:Fitoterapia 2004-06, Vol.75 (3), p.332-336
Main Authors: Ettarh, R.R., Emeka, P.
Format: Article
Language:English
Subjects:
Animals
Aorta - drug effects
Biological and medical sciences
Dose-Response Relationship, Drug
Endothelium
Endothelium, Vascular - drug effects
General pharmacology
Male
Medical sciences
Morinda
Morinda lucida
Nitric oxide
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
Rats
Rats, Sprague-Dawley
Vasodilation - drug effects
Vasodilator Agents - administration & dosage
Vasodilator Agents - pharmacology
Vasodilator Agents - therapeutic use
Vasorelaxation
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Summary:The effect of an aqueous extract of Morinda lucida (ML) on vascular tone was tested using rat aortic rings precontracted with noradrenaline (10 −7 mol/l). Relaxation responses were determined with endothelium-intact, L-NAME-treated, methylene blue-treated and endothelium-denuded tissues. In the concentration range of 0.25–9.0 mg/ml, ML elicited vasorelaxation in noradrenaline-precontracted rings. This relaxation response was partially attenuated by removal of the endothelium, and completely inhibited by pretreatment of rings with L-NAME and methylene blue. Thus, ML-induced relaxation of vascular smooth muscle occurs via endothelium-dependent and -independent mechanisms, the former of which involves the nitric oxide-cGMP pathway.
ISSN:0367-326X
DOI:10.1016/j.fitote.2004.02.003