Oestrogen and attacks of migraine with and without aura

During women's reproductive years, migraine is three times more common than in men of a similar age. Although this female preponderance is commonly assumed to be associated with the additional trigger of fluctuating sex hormones of the menstrual cycle, few studies have been done to confirm or r...

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Bibliographic Details
Published in:Lancet neurology 2004-06, Vol.3 (6), p.354-361
Main Author: Anne MacGregor, E
Format: Article
Language:English
Subjects:
Brain Ischemia - epidemiology
Brain Ischemia - physiopathology
Causality
Clinical Trials as Topic - statistics & numerical data
Comorbidity
Diaries
Dose-Response Relationship, Drug
Estrogens - administration & dosage
Estrogens - blood
Estrogens - metabolism
Female
Follicles
Headaches
Hormones
Humans
Menstrual Cycle - physiology
Menstruation
Migraine
Migraine with Aura - drug therapy
Migraine with Aura - epidemiology
Migraine with Aura - metabolism
Ovaries
Ovulation
Pituitary gland
Risk Factors
Sexes
Treatment Outcome
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Summary:During women's reproductive years, migraine is three times more common than in men of a similar age. Although this female preponderance is commonly assumed to be associated with the additional trigger of fluctuating sex hormones of the menstrual cycle, few studies have been done to confirm or refute this. This review is confined to the relation between oestrogen and attacks of migraine. The evidence for an association between oestrogen “withdrawal” and attacks of migraine without aura is presented, as well as evidence for an association between high oestrogen states and attacks of migraine with aura. Only clinical data are presented here.
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(04)00768-9