Maternal serum levels of interferon‐γ and interleukin‐2 soluble receptor‐α predict the outcome of early IVF pregnancies

BACKGROUND: Elevated maternal serum levels of interleukin‐2 soluble receptor‐α (IL‐2 sRα), tumour necrosis factor‐α (TNF‐α) and interferon‐γ (IFN‐γ) have been associated with pregnancy loss. The aim of our study was to evaluate the predictive value of these cytokines in the outcome of early IVF preg...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2004-06, Vol.19 (6), p.1357-1363
Main Authors: Fasouliotis, S.J., Spandorfer, S.D., Witkin, S.S., Schattman, G., Liu, H.C., Roberts, J.E., Rosenwaks, Z.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Embryology: invertebrates and vertebrates. Teratology
Female
Fertilization in Vitro
Fundamental and applied biological sciences. Psychology
Humans
IFN‐γ/IL‐2 sRα/IVF/pregnancy outcome/TNF‐α
Interferon-gamma - blood
Interleukin-2 Receptor alpha Subunit
Osmolar Concentration
Predictive Value of Tests
Pregnancy
Pregnancy Outcome
Prognosis
Prospective Studies
Receptors, Interleukin - blood
Receptors, Interleukin - chemistry
Solubility
Tumor Necrosis Factor-alpha - analysis
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Summary:BACKGROUND: Elevated maternal serum levels of interleukin‐2 soluble receptor‐α (IL‐2 sRα), tumour necrosis factor‐α (TNF‐α) and interferon‐γ (IFN‐γ) have been associated with pregnancy loss. The aim of our study was to evaluate the predictive value of these cytokines in the outcome of early IVF pregnancies. METHODS: One hundred and fifty‐nine consecutive IVF patients who were subsequently diagnosed to have a biochemical pregnancy (n = 23), a first‐trimester miscarriage (n = 19) or a normal term delivery (n = 117) were included in this study. Serum was collected from the initial pregnancy test, 11 days after a day 3 embryo transfer, and all samples were analysed for IL‐2 sRα, TNF‐α and IFN‐γ by commercially available enzyme‐linked immunosorbent assay (ELISA) kits. RESULTS: IL‐2 sRα levels were significantly higher in patients with an early pregnancy loss compared with patients with a normal term delivery (849.5 ± 69.6 versus 693.5 ± 31.2 pg/ml, P = 0.02), and a cut‐off point of IL‐2 sRα >1000 pg/ml predicted a poor pregnancy outcome (44.4 versus 22.7% pregnancy loss, IL‐2 sRα ≥1000 versus IL‐2 sRα
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/deh169