Prenatal malnutrition-induced hypertension in young rats is prevented by neonatal capsaicin treatment

Prenatal malnutrition-induced fetal growth retardation in the rat results in elevated arterial blood pressure at adulthood. To test the contribution of cardiovascular sensory C fibers in the hypertensive state, arterial blood pressure was measured in prenatally undernourished rats treated at birth w...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2002-08, Vol.328 (3), p.253-256
Main Authors: Pérez, Hernán, Ruiz, Samuel, Soto-Moyano, Rubén
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - physiology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Capsaicin - therapeutic use
Cardiology. Vascular system
Cardiovascular System - innervation
Experimental diseases
Female
Fetal Growth Retardation - etiology
Heart rate
Heart Rate - drug effects
Hypertension
Hypertension - physiopathology
Hypertension - prevention & control
Male
Medical sciences
Neonatal capsaicin
Nerve Fibers - physiology
Nutrition Disorders - complications
Nutrition Disorders - embryology
Pregnancy
Pregnancy Complications
Prenatal malnutrition
Rat
Rats
Rats, Sprague-Dawley
Respiration - drug effects
Unmyelinated C fibers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Prenatal malnutrition-induced fetal growth retardation in the rat results in elevated arterial blood pressure at adulthood. To test the contribution of cardiovascular sensory C fibers in the hypertensive state, arterial blood pressure was measured in prenatally undernourished rats treated at birth with capsaicin. The effects of the neonatal capsaicin treatment on heart rate and respiratory frequency were also evaluated. Maternal malnutrition resulted in body and brain weights deficits in the offspring that were not modified by neonatal capsaicin treatment. Capsaicin treatment did not change the cardiovascular parameters in normal rats, but prevented the elevation of arterial blood pressure and heart rate in malnourished animals. These results indicate that elevation of arterial blood pressure in prenatally malnourished rats depends on the activity of some sensory unmyelinated C fibers.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)00526-8