Prospective, Intensive Study of Metabolic Changes Associated with 48 Weeks of Amprenavir-Based Antiretroviral Therapy

To determine whether a 48-week course of amprenavir-based antiretroviral therapy is associated with metabolic alterations, 14 clinically stable human immunodeficiency virus (HIV)–infected, protease inhibitor–naive adults initiated amprenavir-based triple therapy. Twelve subjects (86%) achieved HIV R...

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Bibliographic Details
Published in:Clinical infectious diseases 2002-08, Vol.35 (4), p.475-481
Main Authors: Dubé, Michael P, Qian, Dajun, Edmondson-Melançon, Hannah, Sattler, Fred R, Goodwin, Diane, Martinez, Carmen, Williams, Vanessa, Johnson, Debra, Buchanan, Thomas A
Format: Article
Language:English
Subjects:
Adult
Anti-HIV Agents - pharmacology
Anti-HIV Agents - therapeutic use
Antiretroviral Therapy, Highly Active
Antiretrovirals
Biological and medical sciences
Body Composition - drug effects
Body fat
Carbamates
Cholesterols
Drug Administration Schedule
Drug toxicity and drugs side effects treatment
Fasting
Female
Glucose - metabolism
Glucose tolerance test
HDL lipoproteins
HIV Infections - drug therapy
HIV Infections - metabolism
HIV/AIDS
Human viral diseases
Humans
Infectious diseases
Insulin
Insulin resistance
Lipid Metabolism
Lipids
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Pilot Projects
Prospective Studies
Sulfonamides - pharmacology
Sulfonamides - therapeutic use
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:To determine whether a 48-week course of amprenavir-based antiretroviral therapy is associated with metabolic alterations, 14 clinically stable human immunodeficiency virus (HIV)–infected, protease inhibitor–naive adults initiated amprenavir-based triple therapy. Twelve subjects (86%) achieved HIV RNA levels of
ISSN:1058-4838
1537-6591
DOI:10.1086/341489