Trypanocidal properties of Mikania stipulacea and Mikania hoehnei isolated terpenoids

The in vitro trypanocidal properties of isolated terpenoids from Mikania stipulacea and Mikania hoehnei were investigated in Trypanosoma cruzi Y strain. Both compounds, the diterpene ent-9α-hydroxy-15β- E-cinnamoyloxy-16-kauren-19-oic acid ( 1) and the sesquiterpene lactone 8β-hydroxyzaluzanin D ( 2...

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Bibliographic Details
Published in:Fitoterapia 2004-06, Vol.75 (3), p.381-384
Main Authors: Mendes do Nascimento, Andréa, Siqueira Chaves, Juliana, Albuquerque, Sérgio, Camilo Rodrigues de Oliveira, Dionéia
Format: Article
Language:English
Subjects:
8β-hydroxyzaluzanin D
Animals
Biological and medical sciences
Chagas Disease - prevention & control
ent-9α-hydroxy-15β- E-cinnamoyloxy-16-kauren-19-oic acid
General pharmacology
Humans
Medical sciences
Mikania
Mikania hoehnei
Mikania stipulacea
Parasitic Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Terpenes - administration & dosage
Terpenes - pharmacology
Terpenes - therapeutic use
Trypanocidal activity
Trypanocidal Agents - administration & dosage
Trypanocidal Agents - pharmacology
Trypanocidal Agents - therapeutic use
Trypanosoma cruzi
Trypanosoma cruzi - drug effects
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Summary:The in vitro trypanocidal properties of isolated terpenoids from Mikania stipulacea and Mikania hoehnei were investigated in Trypanosoma cruzi Y strain. Both compounds, the diterpene ent-9α-hydroxy-15β- E-cinnamoyloxy-16-kauren-19-oic acid ( 1) and the sesquiterpene lactone 8β-hydroxyzaluzanin D ( 2) were active.
ISSN:0367-326X
DOI:10.1016/j.fitote.2004.01.013