The 3,4-Dihydroxyl Groups are Important for trans-Resveratrol Analogs to Exhibit Enhanced Antioxidant and Apoptotic Activities

We compared the abilities of trans-resveratrol and seven analogs to inhibit an azo compound-induced peroxidation of linoleic acid in vitro and to induce apoptosis in cultured human leukemia cells. The results showed that both the antioxidant and apoptotic activities of the analogs containing 3,4-dih...

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Bibliographic Details
Published in:Anticancer research 2004-03, Vol.24 (2B), p.999-1002
Main Authors: CAI, Yu-Jun, WEI, Qing-Yi, FANG, Jian-Guo, LI YANG, LIU, Zhong-Li, WYCHE, James H, ZHIYONG HAN
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants - chemistry
Antioxidants - pharmacology
Apoptosis - drug effects
Azo Compounds - chemistry
Biological and medical sciences
HL-60 Cells
Humans
Jurkat Cells
Linoleic Acid - chemistry
Linoleic Acid - metabolism
Lipid Peroxidation - drug effects
Medical sciences
Stilbenes - chemistry
Stilbenes - pharmacology
Structure-Activity Relationship
Tumors
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Summary:We compared the abilities of trans-resveratrol and seven analogs to inhibit an azo compound-induced peroxidation of linoleic acid in vitro and to induce apoptosis in cultured human leukemia cells. The results showed that both the antioxidant and apoptotic activities of the analogs containing 3,4-dihydroxyl groups were significantly higher than those of the trans-resveratrol and the other analogs. Hence, the 3,4-dihydroxyl groups were important for trans-resveratrol analogs to exhibit concurrent high antioxidant and apoptotic activities.
ISSN:0250-7005
1791-7530