Molecular and functional characteristics of erbB2 in normal and cancer breast cells
The expression pattern of erbB2 and its transmembrane polymorphisms (Ile 654Val and Ile 655Val) were investigated in a panel of human normal and neoplastic breast cell lines to evaluate whether the expression pattern was affected by changes in the gene structure. At least two peptides of lower molec...
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Published in: | Cancer letters 2004-06, Vol.209 (2), p.215-222 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The expression pattern of erbB2 and its transmembrane polymorphisms (Ile
654Val and Ile
655Val) were investigated in a panel of human normal and neoplastic breast cell lines to evaluate whether the expression pattern was affected by changes in the gene structure. At least two peptides of lower molecular mass forms (95 and 68 kDa) than the holoreceptor (185 kDa), comprehensive of the tyrosine kinase domain, were detected in all cells. Both peptides were also phosphorylated, suggesting a functional role in signal transduction. The presence of the polymorphisms found in two cell lines was unrelated to the expression of the lower molecular mass proteins. |
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ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/j.canlet.2003.12.014 |