Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever

In Iquitos, Peru, no cases of dengue haemorrhagic fever have been recorded in individuals infected with dengue-1 virus followed by American genotype dengue-2 (American dengue-2) virus. We assayed serum samples collected in Iquitos that tested positive for antibodies of monotype dengue-1 and monotype...

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Bibliographic Details
Published in:The Lancet (British edition) 2002-07, Vol.360 (9329), p.310-312
Main Authors: Kochel, Tadeusz J, Watts, Douglas M, Halstead, Scott B, Hayes, Curtis G, Espinoza, Angelica, Felices, Vidal, Caceda, Roxana, Bautista, Christian T, Montoya, Ysabel, Douglas, Susan, Russell, Kevin L
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
Arboviroses
Biological and medical sciences
Dengue - immunology
Dengue fevers
Dengue Virus - classification
Dengue Virus - immunology
Drug therapy
Fever
Human viral diseases
Humans
Infections
Infectious diseases
Medical research
Medical sciences
Peru
Polymerase Chain Reaction
Serotyping
Severe Dengue - immunology
Tropical medicine
Tropical viral diseases
Vector-borne diseases
Viral diseases
Viruses
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Summary:In Iquitos, Peru, no cases of dengue haemorrhagic fever have been recorded in individuals infected with dengue-1 virus followed by American genotype dengue-2 (American dengue-2) virus. We assayed serum samples collected in Iquitos that tested positive for antibodies of monotype dengue-1 and monotype dengue-2 using a plaque reduction neutralisation test to determine their ability to neutralise the infectivity of two dengue-1 viruses, two American dengue-2 viruses, and two Asian dengue-2 viruses. Sera positive for the dengue-1 antibody neutralised dengue-1 viruses and American dengue-2 viruses much more effectively than Asian dengue-2 viruses. Neutralisation of American dengue-2 virus by sera positive for dengue-1 antibodies may account for the absence of dengue haemorrhagic fever in individuals infected with dengue-1 in 1990–91 followed by American dengue-2 virus in 1995 in Iquitos, Peru.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(02)09522-3