Estimated biological variation of the mature human milk fatty acid composition

We estimated the biological variation (CV(biol)) of 28 fatty acids (FA) in 465 mature human milk samples from The Netherlands, Caribbean, Jerusalem, Tanzania and Pakistan, by using data from the observed variation (CV(obs)) and analytical variation (CV(anal)). CV(biol) of the various regions was rem...

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Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2002-05, Vol.66 (5-6), p.549-555
Main Authors: SMIT, E. N, MARTINI, I. A, MULDER, H, BOERSMA, E. R, MUSKIET, F. A. J
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Biological and medical sciences
Biometry
Caribbean Region
Diet
Fatty Acids - analysis
Fatty Acids - metabolism
Female
Fundamental and applied biological sciences. Psychology
Humans
Longitudinal Studies
Milk, Human - chemistry
Milk, Human - metabolism
Mother. Fetoplacental unit. Mammary gland. Milk
Netherlands
Pakistan
Pregnancy. Parturition. Lactation
Tanzania
Vertebrates: reproduction
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Summary:We estimated the biological variation (CV(biol)) of 28 fatty acids (FA) in 465 mature human milk samples from The Netherlands, Caribbean, Jerusalem, Tanzania and Pakistan, by using data from the observed variation (CV(obs)) and analytical variation (CV(anal)). CV(biol) of the various regions was remarkably similar. The average CV(biol) of 455 samples, Pakistan excluded, ranged from 12.7% for 16:0 and 18.9% for 18:1 omega 9 to 68% for 22:6 omega 3 and about 100% for 20:5 omega 3. Those of 20:4 omega 6, 18:2 omega 6 and 18:3 omega 3 were 28.0, 33.0 and 37.3%, respectively. Because of the large CV(biol) and the many dietary changes in recent history, it seems impossible to consider the present human milk FA composition as the 'gold standard' for infant formula. Optimal human milk FA composition should rather derive from populations that consume traditional diets or from the scientific data that show the function of the individual FAs in neonatal development.
ISSN:0952-3278
1532-2823
DOI:10.1054/plef.2002.0398