Characteristics of Skin Surface Morphology and Transepidermal Water Loss in Clinically Normal‐Appearing Skin of Patients with Atopic Dermatitis: A Video‐Microscopy Study

In patients with atopic dermatitis (AD), it is debatable whether clinically normal‐appearing skin is equal to non‐atopic normal skin. The aim of this study was to quantitatively evaluate the characteristics of normal‐appearing skin of AD. We examined the value of skin surface morphological changes u...

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Bibliographic Details
Published in:Journal of dermatology 2004-02, Vol.31 (2), p.78-85
Main Authors: Suehiro, Mitsuhiro, Hirano, Shinya, Ikenaga, Kenji, Katoh, Norito, Yasuno, Hirokazu, Kishimoto, Saburo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Case-Control Studies
clinical score
Dermatitis, Atopic - physiopathology
disease activity
eosinophil
Female
Humans
Image Processing, Computer-Assisted
lactate dehydrogenase
Male
Microscopy, Video
Middle Aged
Severity of Illness Index
Skin Physiological Phenomena
skin ridges
Water Loss, Insensible
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Summary:In patients with atopic dermatitis (AD), it is debatable whether clinically normal‐appearing skin is equal to non‐atopic normal skin. The aim of this study was to quantitatively evaluate the characteristics of normal‐appearing skin of AD. We examined the value of skin surface morphological changes using a new, simple, computer‐assisted method with a video microscope. We also investigated the physiological function as represented by transepidermal water loss (TEWL) levels in 44 patients with AD and 15 normal controls. The morphological changes were represented by a variation coefficient score that reflected the irregularity of skin ridges, named the surface irregularity index (SII). There were significant differences between the normal‐appearing skin of AD and non‐atopic normal skin in both SII (P
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.2004.tb00512.x