Innate immune recognition of microbes through Nod1 and Nod2: implications for disease

Nod1 and Nod2 are cytosolic proteins involved in intracellular recognition of microbes and their products. Recently, it was shown that these proteins recognize different moieties of bacterial peptidoglycan (PGN) mediating non-specific pathogen resistance and possibly generating signals for the adapt...

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Bibliographic Details
Published in:Microbes and Infection 2004-05, Vol.6 (6), p.609-616
Main Authors: Carneiro, Leticia A.M., Travassos, Leonardo H., Philpott, Dana J.
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - immunology
Apoptosis
Bacteria - chemistry
Bacteria - immunology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Humans
Immunity, Innate
Inflammation
Innate immunity
Intracellular Signaling Peptides and Proteins - immunology
Microbiology
Nod1
Nod1 Signaling Adaptor Protein
Nod2
Nod2 Signaling Adaptor Protein
Peptidoglycan
Peptidoglycan - immunology
Peptidoglycan - metabolism
Toll-like receptors
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Summary:Nod1 and Nod2 are cytosolic proteins involved in intracellular recognition of microbes and their products. Recently, it was shown that these proteins recognize different moieties of bacterial peptidoglycan (PGN) mediating non-specific pathogen resistance and possibly generating signals for the adaptive immune response. Moreover, mutations in the gene encoding Nod2 are associated with increased susceptibility to chronic inflammatory disorders.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2004.01.012