Massive Number of Antigen-Specific CD4 T Cells during Vaccination with Live Attenuated Salmonella Causes Interclonal Competition

The clonal burst size of CD4 T cells is predicted to be less than that of CD8 T cells. In this study, we demonstrate that massive numbers of Ag-specific CD4 T cells respond during vaccination of mice with live attenuated Salmonella, reaching a peak frequency of approximately 50% of CD4 T cells. Salm...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2004-06, Vol.172 (11), p.6884-6893
Main Authors: Srinivasan, Aparna, Foley, Joseph, McSorley, Stephen J
Format: Article
Language:English
Subjects:
Adoptive Transfer
Animals
CD11a Antigen - analysis
CD4-Positive T-Lymphocytes - immunology
Immunologic Memory
Interferon-gamma - biosynthesis
Mice
Mice, Inbred C57BL
Mice, Transgenic
Receptors, Antigen, T-Cell - physiology
Salmonella
Salmonella Vaccines - immunology
Vaccination
Vaccines, Attenuated - immunology
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Summary:The clonal burst size of CD4 T cells is predicted to be less than that of CD8 T cells. In this study, we demonstrate that massive numbers of Ag-specific CD4 T cells respond during vaccination of mice with live attenuated Salmonella, reaching a peak frequency of approximately 50% of CD4 T cells. Salmonella-specific T cells persisted at high frequency for several weeks and could be detected in the memory population for months after infection. Surprisingly, the expansion of endogenous Salmonella-specific CD4 T cells prevented the persistence of adoptively transferred Salmonella-specific T cells in vivo, demonstrating interclonal competition for access to the memory compartment.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.172.11.6884