Determination of Molecular Marker Expression Can Predict Clinical Outcome in Colon Carcinomas

Purpose: Conventional staging procedures are often unable to precisely predict prognosis in colorectal cancer (CRC). In this study, we set out to investigate the possible role of molecular/structural indicators involved in cell cycle regulation (p27 and p53), apoptosis (p53 and p27), and tumor neoan...

Full description

Saved in:
Bibliographic Details
Published in:Clinical cancer research 2004-05, Vol.10 (10), p.3490-3499
Main Authors: GALIZIA, Gennaro, LIETO, Eva, PIGNATELLI, Carlo, FERRARACCIO, Francesca, ORDITURA, Michele, DE VITA, Ferdinando, CASTELLANO, Paolo, IMPERATORE, Vincenzo, ROMANO, Ciro, CIARDIELLO, Fortunato, AGOSTINI, Bruno
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic agents
Apoptosis
Biological and medical sciences
Cell Cycle Proteins - metabolism
Cell Nucleus - metabolism
Colon - pathology
Colonic Neoplasms - diagnosis
Colonic Neoplasms - metabolism
Colonic Neoplasms - mortality
Cyclin-Dependent Kinase Inhibitor p27
Disease-Free Survival
Female
Humans
Immunohistochemistry
Male
Medical sciences
Microcirculation
Middle Aged
Mucous Membrane - pathology
Multivariate Analysis
Neovascularization, Pathologic
Pharmacology. Drug treatments
Prognosis
Proportional Hazards Models
Recurrence
Time Factors
Treatment Outcome
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Proteins - metabolism
Tumors
Vascular Endothelial Growth Factor A - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: Conventional staging procedures are often unable to precisely predict prognosis in colorectal cancer (CRC). In this study, we set out to investigate the possible role of molecular/structural indicators involved in cell cycle regulation (p27 and p53), apoptosis (p53 and p27), and tumor neoangiogenesis [p53, vascular endothelial growth factor (VEGF), and microvessel count] in predicting tumor behavior and clinical outcome in CRC patients Experimental Design: Analysis of the above indicators was performed by immunohistochemistry on 104 CRC patient samples and 25 normal colon mucosa specimens. Results: Intense p27 nuclear staining was found in normal colon mucosa, with p53 nuclear staining and VEGF cytoplasmic accumulation
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-0960-03