Prevalence of stimulant use for attentional dysfunction in children with phenylketonuria

Sumary: Recent data suggest that children with phenylketonuria (PKU) and poor metabolic control may have an increased prevalence of attentional dysfunction. However, few formal studies have addressed this topic in detail. We reviewed the medical records of 38 school‐aged children with early and cont...

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Published in:Journal of inherited metabolic disease 2004-01, Vol.27 (2), p.137-143
Main Authors: Arnold, G. L., Vladutiu, C. J., Orlowski, C. C., Blakely, E. M., DeLuca, J.
Format: Article
Language:English
Subjects:
Adolescent
Attention
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - epidemiology
Biological and medical sciences
Central Nervous System Stimulants - therapeutic use
Child
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Humans
Male
Molecular and cellular biology
Phenylalanine - blood
Phenylketonurias - blood
Phenylketonurias - epidemiology
Prevalence
Retrospective Studies
Tyrosine - deficiency
Tyrosine - therapeutic use
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Sumary: Recent data suggest that children with phenylketonuria (PKU) and poor metabolic control may have an increased prevalence of attentional dysfunction. However, few formal studies have addressed this topic in detail. We reviewed the medical records of 38 school‐aged children with early and continuously treated PKU to determine the prevalence of stimulant use for attentional dysfunction, and to determine the relationship between metabolic control and attentional symptoms. Twenty‐six per cent of the PKU children used a stimulant medication for attentional dysfunction. This is significantly higher than in an age‐ and sex‐matched control group consisting of children with type I diabetes mellitus (6.5%, p
ISSN:0141-8955
1573-2665
DOI:10.1023/B:BOLI.0000028725.37345.62