What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

The present review illustrates the current knowledge on the autocrine effect of IL-12, and the putative contribution of IL-23, on macrophages and dendritic cells, focusing on cell activation and microbicidal activity. Here, we present convincing evidence that IL-12 is not only a connective element b...

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Bibliographic Details
Published in:Microbes and Infection 2004-05, Vol.6 (6), p.630-636
Main Authors: Bastos, Karina R.B., Marinho, Claudio R.F., Barboza, Renato, Russo, Momtchilo, Álvarez, José M., D’Império Lima, Maria Regina
Format: Article
Language:English
Subjects:
Animals
Antigen-Presenting Cells - immunology
Antigen-Presenting Cells - metabolism
Biological and medical sciences
Dendritic cell
Dendritic Cells - immunology
Fundamental and applied biological sciences. Psychology
Humans
IFN-γ
IL-12
IL-23
Interleukin-12 - immunology
Interleukin-12 - physiology
Interleukin-23
Interleukin-23 Subunit p19
Interleukins - immunology
Interleukins - physiology
Macrophage
Macrophage Activation
Macrophages - immunology
Microbiology
Nitric oxide
Signal Transduction
TGF-β1
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Summary:The present review illustrates the current knowledge on the autocrine effect of IL-12, and the putative contribution of IL-23, on macrophages and dendritic cells, focusing on cell activation and microbicidal activity. Here, we present convincing evidence that IL-12 is not only a connective element between accessory cells and lymphocytes, but it is also a key molecule for programming the macrophage and dendritic cell functions.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2004.02.012