Rapid and sensitive p53 alteration analysis in biopsies from lung cancer patients Using a functional assay and a universal oligonucleotide array: A prospective study

Molecular profiling of alterations associated with lung cancer holds the promise to define clinical parameters such as response to treatment or survival. Because

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Bibliographic Details
Published in:Clinical cancer research 2004-05, Vol.10 (10), p.3479-3489
Main Authors: FOUQUET, Coralie, ANTOINE, Martine, CADRANEL, Jacques, ZALCMAN, Gérard, SOUSSI, Thierry, TISSERAND, Pascaline, FAVIS, Reyna, WISLEZ, Marie, COMMO, Fréderic, RABBE, Nathalie, CARETTE, Marie France, MILLERON, Bernard, BARANY, Francis
Format: Article
Language:English
Subjects:
Aged
Alleles
Antineoplastic agents
Biological and medical sciences
Biopsy
Cohort Studies
DNA - metabolism
DNA Mutational Analysis - methods
Female
Genes, p53
Humans
Lung Neoplasms - diagnosis
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Male
Medical sciences
Middle Aged
Mutation
Nucleic Acids - metabolism
Oligonucleotide Array Sequence Analysis
Oligonucleotides - genetics
Pharmacology. Drug treatments
Plasmids - metabolism
Polymerase Chain Reaction
Prospective Studies
Reverse Transcriptase Polymerase Chain Reaction
RNA - metabolism
Sensitivity and Specificity
Tumor Suppressor Protein p53 - metabolism
Tumors
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Description
Summary:Molecular profiling of alterations associated with lung cancer holds the promise to define clinical parameters such as response to treatment or survival. Because
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-0994-03