Electron Conduction across Electrode-Immobilized Neutravidin Bound with Biotin-Labeled Ruthenium Pentaamine

Voltammetry is reported here of a self-assembled redox-protein conjugate consisting of neutravidin conjugated with a biotin derivative redox probe, Ru(NH3)5(N-[(N-[(4-pyridyl)methyl]biotinamide], immobilized on gold electrodes modified by self-assembled monolayers of mercaptoundecanoic acid. This vo...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-06, Vol.126 (21), p.6540-6541
Main Authors: Jhaveri, Sulay D, Trammell, Scott A, Lowy, Daniel A, Tender, Leonard M
Format: Article
Language:English
Subjects:
Amines - chemistry
Amines - metabolism
Avidin - chemistry
Avidin - metabolism
Biological and medical sciences
Biotin - chemistry
Electrochemistry
Electrodes
Electrons
Fundamental and applied biological sciences. Psychology
Models, Molecular
Molecular biophysics
Molecular Structure
Organometallic Compounds - chemistry
Organometallic Compounds - metabolism
Physical chemistry in biology
Propionates - chemistry
Ruthenium - chemistry
Ruthenium - metabolism
Staining and Labeling
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Summary:Voltammetry is reported here of a self-assembled redox-protein conjugate consisting of neutravidin conjugated with a biotin derivative redox probe, Ru(NH3)5(N-[(N-[(4-pyridyl)methyl]biotinamide], immobilized on gold electrodes modified by self-assembled monolayers of mercaptoundecanoic acid. This voltammetry indicates that self-assembly of the conjugate/electrode electronic interface, driven by electrostatic binding between the monolayer and a single redox probe, favors orientation of the conjugate, resulting in electronic accessibility of the remaining three redox probes.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja037949g