Osteoblast responses to tape-cast and sintered bioactive glass ceramics

The advantage of tape‐cast bioactive glasses lies in the manufacturing procedure, which allows the build‐up of layers and, therefore, the production of complex shapes. This, therefore, has applications to tissue engineering, where specific shapes are required such as repair of craniofacial defects....

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Bibliographic Details
Published in:Journal of biomedical materials research 2004-06, Vol.69A (4), p.621-628
Main Authors: Gough, J. E., Clupper, D. C., Hench, L. L.
Format: Article
Language:English
Subjects:
Apoptosis - physiology
bioactive
Biocompatible Materials
Cell Adhesion - physiology
Cell Culture Techniques
Ceramics
Culture Media
Durapatite - analysis
Durapatite - metabolism
Humans
Hydrogen-Ion Concentration
Osteoblasts - physiology
primary human osteoblasts
Spectroscopy, Fourier Transform Infrared
tape cast
Time Factors
tissue engineering
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Summary:The advantage of tape‐cast bioactive glasses lies in the manufacturing procedure, which allows the build‐up of layers and, therefore, the production of complex shapes. This, therefore, has applications to tissue engineering, where specific shapes are required such as repair of craniofacial defects. The bioactivity of tape‐cast discs sintered at temperatures ranging from 800°C to 1000°C and for 3 or 6 h was analyzed by FTIR. Tape‐cast discs were used to culture primary human osteoblasts, and cell attachment, cell death, collagen production, nodule formation, and mineralization were studied. These responses were dependent upon Si and Na release profiles of the tape‐cast discs, and development of the hydroxyapatite layer. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 69A: 621–628, 2004
ISSN:1549-3296
0021-9304
1552-4965
1097-4636
DOI:10.1002/jbm.a.30024