Recognition of HLA‐A3 and HLA‐A11 by KIR3DL2 is peptide‐specific

The recognition of MHC class I molecules by killer cell immunoglobulin‐like receptors (KIR) is central to the control of NK cell function and can also modulate the CTL activation threshold. Among KIR receptors, KIR3DL2 is thought to interact with HLA‐A3 and ‐A11, although direct evidence has been la...

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Bibliographic Details
Published in:European journal of immunology 2004-06, Vol.34 (6), p.1673-1679
Main Authors: Hansasuta, Pokrath, Dong, Tao, Thananchai, Hathairat, Weekes, Michael, Willberg, Christian, Aldemir, Hatice, Rowland‐Jones, Sarah, Braud, Veronique M.
Format: Article
Language:English
Subjects:
EBV
Flow Cytometry
HLA-A Antigens - immunology
HLA-A11 Antigen
HLA-A3 Antigen - immunology
Humans
Killer Cells, Natural - immunology
KIR receptors
KIR3DL2
NK cell
Peptide Fragments
Protein Conformation
Receptors, Immunologic - immunology
Receptors, KIR
Receptors, KIR3DL2
T-Lymphocytes, Cytotoxic - immunology
Tetramers
Transfection
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Summary:The recognition of MHC class I molecules by killer cell immunoglobulin‐like receptors (KIR) is central to the control of NK cell function and can also modulate the CTL activation threshold. Among KIR receptors, KIR3DL2 is thought to interact with HLA‐A3 and ‐A11, although direct evidence has been lacking. In this study, we show that HLA‐A3 and ‐A11 tetramers specifically bind to KIR3DL2*001 transfectants and that this recognition is peptide‐specific. Single amino acid substitutions in the nonamer peptide underline a critical role for residue 8 in recognition of KIR3DL2. However, the role of this interaction in vivo still remains to be established.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.200425089