A potential antitumor peptide therapeutic derived from antineoplastic urinary protein

New therapies in cancer treatment are focusing on multifaceted approaches to starve and kill tumors utilizing both antiangiogenic and chemotherapeutic compounds. Antineoplastic Urinary Protein (ANUP), a 32 kDa protein normally secreted in human urine, has been previously described as a molecule poss...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2004-04, Vol.25 (4), p.543-549
Main Authors: Hehir, Kathleen M, Baguisi, Alexander, Pennington, Sarah E, Bates, Janna M, DiTullio, Paul A
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Antigens, Ly - administration & dosage
Antineoplastic urinary protein
ANUP
Biological and medical sciences
CAM
Chick Embryo
Cost of Illness
Female
Fundamental and applied biological sciences. Psychology
HeLa Cells
Humans
Mice
Mice, Nude
Neoplasms, Experimental - blood supply
Neoplasms, Experimental - drug therapy
Neovascularization, Pathologic - drug therapy
Neovascularization, Pathologic - pathology
Peptides - administration & dosage
Urokinase-Type Plasminogen Activator - administration & dosage
Vertebrates: endocrinology
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Summary:New therapies in cancer treatment are focusing on multifaceted approaches to starve and kill tumors utilizing both antiangiogenic and chemotherapeutic compounds. Antineoplastic Urinary Protein (ANUP), a 32 kDa protein normally secreted in human urine, has been previously described as a molecule possessing both antiproliferative and antiangiogenic activities. Two synthetic peptides complimentary to the N-terminus of ANUP were designed to test their ability to reproduce these beneficial effects but ultimately to provide a more useful small molecule therapeutic. The results show that the peptides reduced tumor burden by up to 70% in a nude mouse model and demonstrated the ability to inhibit blood vessel formation in a chick chorioallantoic membrane assay (CAM).
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2004.02.003