Enzymatic catalysis of the Diels-Alder reaction in the biosynthesis of natural products

Recent studies on enzymes catalyzing the Diels- Alder reaction. often named "Diels-Alderases", clearlydemonstrated the involvement of this synthetically useful reaction in the biosynthesis of natural products.This review covers natural Diels-Alder type cycloadducts. synthetic efforts on th...

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Bibliographic Details
Published in:Natural product reports 2004-06, Vol.21 (3), p.321-352
Main Authors: Oikawa, Hideaki, Tokiwano, Tetsuo
Format: Article
Language:English
Subjects:
Alkaloids - biosynthesis
Alkaloids - chemistry
Biological Products - biosynthesis
Biological Products - chemistry
Catalysis
Cyclization
Macrolides - chemical synthesis
Macrolides - chemistry
Molecular Structure
Structure-Activity Relationship
Terpenes - chemical synthesis
Terpenes - chemistry
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Summary:Recent studies on enzymes catalyzing the Diels- Alder reaction. often named "Diels-Alderases", clearlydemonstrated the involvement of this synthetically useful reaction in the biosynthesis of natural products.This review covers natural Diels-Alder type cycloadducts. synthetic efforts on the chemical feasibility ofthe biosynthctic Diels - Alder reaction and a brief history of studies on Diels-Alderases. In addition,reaction mechanisms of artificial and natural Diels--Alderases are discussed.
ISSN:0265-0568
1460-4752
DOI:10.1039/b305068h