Relevance of homocysteine on brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness in patients with hypercholesterolemia

The relevance of homocysteine to brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness was investigated in 192 patients with hypercholesterolemia. Low-density lipoprotein cholesterol and homocysteine levels predicted brachial flow-mediated vasodilatation, internal caro...

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Bibliographic Details
Published in:The American journal of cardiology 2004-06, Vol.93 (11), p.1413-1416
Main Authors: Vaudo, Gaetano, Marchesi, Simona, Siepi, Donatella, Bagaglia, Francesco, Paltriccia, Rita, Pirro, Matteo, Schillaci, Giuseppe, Lupattelli, Graziana, Mannarino, Elmo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood vessels
Brachial Artery - diagnostic imaging
Brachial Artery - physiology
Cardiology. Vascular system
Carotid Artery, Internal - diagnostic imaging
Carotid Artery, Internal - pathology
Case-Control Studies
Cholesterol
Cholesterol, LDL - blood
Circulatory system
Disorders of blood lipids. Hyperlipoproteinemia
Female
Femoral Artery - diagnostic imaging
Femoral Artery - pathology
Heart
Homocysteine - blood
Humans
Hypercholesterolemia - pathology
Hypercholesterolemia - physiopathology
Male
Medical sciences
Metabolic diseases
Middle Aged
Patients
Proteins
Regional Blood Flow - physiology
Regression Analysis
Risk Factors
Tunica Intima - pathology
Tunica Media - pathology
Ultrasonography
Vasodilation - physiology
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Summary:The relevance of homocysteine to brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness was investigated in 192 patients with hypercholesterolemia. Low-density lipoprotein cholesterol and homocysteine levels predicted brachial flow-mediated vasodilatation, internal carotid mean intima-media thickness, and intima-media thickening at all femoral sites. Homocysteine levels seem to be an additional factor in the initial atherosclerotic damage of patients with hypercholesterolemia.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.02.044