Organogenesis of kidneys following transplantation of renal progenitor cells

One novel solution to the shortage of human organs available for transplantation envisions ‘growing’ new organs in situ via xenotransplantation of developing anlagen from animal embryos. We and others have shown that renal progenitor cells (metanephroi) transplanted into animal hosts undergo organog...

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Bibliographic Details
Published in:Transplant immunology 2004-04, Vol.12 (3), p.229-239
Main Author: Hammerman, Marc R
Format: Article
Language:English
Subjects:
Animals
Cell Transplantation
Cell- and Tissue-Based Therapy
Dialysis
Fetal Tissue Transplantation
Humans
Kidney
Kidney - cytology
Kidney - embryology
Kidney - growth & development
Kidney Diseases - pathology
Kidney Diseases - therapy
Metanephros
Mice
Nephron
Organogenesis
Rats
Stem Cells
Swine
Transplantation
Transplantation, Heterologous
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Summary:One novel solution to the shortage of human organs available for transplantation envisions ‘growing’ new organs in situ via xenotransplantation of developing anlagen from animal embryos. We and others have shown that renal progenitor cells (metanephroi) transplanted into animal hosts undergo organogenesis (differentiation and growth), become vascularized by blood vessels of host origin and exhibit excretory function. Metanephroi can be stored for up to 3 days in vitro prior to transplantation with no impairment in growth or function post-implantation. Metanephroi can be transplanted across both concordant (rat to mouse) and highly disparate (pig to rodent) xenogeneic barriers. Here we review studies exploring the potential therapeutic use of embryonic kidney transplantation as a means to achieve renal organogenesis.
ISSN:0966-3274
1878-5492
DOI:10.1016/j.trim.2003.12.002