Increased serum levels of interleukin-8 in polyarteritis nodosa and Behçet's disease

The pathogenesis of Behçet's disease (BD) and polyarteritis nodosa (PAN) is not yet well established. Endothelial cells have been shown to express chemokines that are involved in inflammatory processes. Interleukin-8 (IL-8) is a potent chemoattractant and activator of neutrophils. We evaluated...

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Bibliographic Details
Published in:Clinical rheumatology 2004-06, Vol.23 (3), p.203-205
Main Authors: Freire, Alzírton de Lira, Bertolo, Manoel Barros, de Pinho, Jr, Antônio José, Samara, Adil Muhib, Fernandes, Sandra Regina Muchinechi
Format: Article
Language:English
Subjects:
Adult
Behcet Syndrome - blood
Behcet Syndrome - immunology
Disease
Enzymes
Female
Humans
Interleukin-8 - blood
Interleukin-8 - immunology
Male
Medical research
Middle Aged
Pathogenesis
Polyarteritis Nodosa - blood
Polyarteritis Nodosa - immunology
Severity of Illness Index
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Summary:The pathogenesis of Behçet's disease (BD) and polyarteritis nodosa (PAN) is not yet well established. Endothelial cells have been shown to express chemokines that are involved in inflammatory processes. Interleukin-8 (IL-8) is a potent chemoattractant and activator of neutrophils. We evaluated serum IL-8 levels in patients with PAN and BD. We measured serum IL-8 levels in 21 patients with BD and 16 with PAN. Sera from 30 age-matched healthy blood donors were used as normal controls. Serum IL-8 levels were measured by an enzyme-linked immunosorbent assay (ELISA). The mean serum IL-8 level of the active BD (1522.31 pg/ml) and that of the active PAN (654.8 pg/ml) was significantly higher than that of the normal controls (40.39 pg/ml, P
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-003-0851-x