R353Q Polymorphism, Activated Factor VII, and Risk of Premature Myocardial Infarction in Japanese Men

Background The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial. Methods and Results The present case - control study...

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Published in:Circulation Journal 2004, Vol.68(6), pp.520-525
Main Authors: Ogawa, Masakazu, Abe, Satoshi, Biro, Sadatoshi, Saigo, Masahiko, Kihara, Takashi, Setoyama, Shiro, Matsuoka, Tatsuru, Toda, Hitoshi, Torii, Hiroyuki, Atsuchi, Yoshihiko, Toyama, Yoshifumi, Tateishi, Shigeki, Minagoe, Shinichi, Maruyama, Ikuro, Tei, Chuwa
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Case-Control Studies
Coronary risk factor
DNA Mutational Analysis
Factor VII
Factor VIIa - analysis
Factor VIIa - genetics
Gene Frequency
Genotype
Humans
Japan - epidemiology
Male
Myocardial Infarction - epidemiology
Myocardial Infarction - etiology
Myocardial Infarction - genetics
Odds Ratio
Polymorphism, Single Nucleotide
Premature myocardial infarction
R353Q polymorphism
Risk
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Summary:Background The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial. Methods and Results The present case - control study in 127 Japanese men with their first MI at or before 45 years of age and 150 matched healthy controls was designed to clarify this association in premature MI. R353Q polymorphism was determined by polymerase chain reaction, and plasma concentrations of FVIIa and FVIIag were assayed. The distribution of the RR, RQ, and QQ genotypes with respect to R353Q polymorphism was 117, 10, and 0 in the patients, and 131, 17, and 2 in the controls. The Q allele was negatively associated with premature MI (odds ratio =0.41, p=0.038). The plasma concentration of FVIIa was slightly higher in patients (55.1±40.9 U/L) than in controls (44.8±20.2 U/L), but not significantly (p=0.078); the plasma concentration of FVIIag did not differ between patients (88.7±15.7%) and controls (87.0±9.0%) (p=0.557). Plasma FVIIa concentrations were influenced by R353Q polymorphism (p
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.68.520