CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans

The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encod...

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Published in:Immunogenetics (New York) 2004-05, Vol.56 (2), p.107-110
Main Authors: Stanton, Tara, Boxall, Sally, Bennett, Andrea, Kaleebu, Pontiano, Watera, Christine, Whitworth, Jimmy, French, Neil, Dawes, Ritu, Hill, Adrian V S, Bodmer, Walter, Beverley, Peter C L, Tchilian, Elma Z
Format: Article
Language:English
Subjects:
Alternative Splicing
Amino Acid Substitution
Amino acids
Exons - genetics
Gene Frequency
Genetic Predisposition to Disease
HIV
HIV Infections - genetics
HIV Infections - immunology
HIV Seropositivity
HIV-1
Human immunodeficiency virus
Humans
Leukocyte Common Antigens - genetics
Leukocyte Common Antigens - metabolism
Leukocytes, Mononuclear - immunology
Lymphocytes
Polymorphism, Genetic - genetics
Proteins
Uganda
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container_end_page 110
container_issue 2
container_start_page 107
container_title Immunogenetics (New York)
container_volume 56
creator Stanton, Tara
Boxall, Sally
Bennett, Andrea
Kaleebu, Pontiano
Watera, Christine
Whitworth, Jimmy
French, Neil
Dawes, Ritu
Hill, Adrian V S
Bodmer, Walter
Beverley, Peter C L
Tchilian, Elma Z
description The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encoding CD45 (PTPRC) that results in an amino acid substitution of Thr-19 to Ala in exon 4. The 54G allele was identified in African Ugandan populations and was found with a suggestive but not statistically significant increase in frequency amongst HIV-seropositive Ugandans. This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection.
doi_str_mv 10.1007/s00251-004-0668-z
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identifier ISSN: 0093-7711
ispartof Immunogenetics (New York), 2004-05, Vol.56 (2), p.107-110
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1432-1211
language eng
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source Springer Nature
subjects Alternative Splicing
Amino Acid Substitution
Amino acids
Exons - genetics
Gene Frequency
Genetic Predisposition to Disease
HIV
HIV Infections - genetics
HIV Infections - immunology
HIV Seropositivity
HIV-1
Human immunodeficiency virus
Humans
Leukocyte Common Antigens - genetics
Leukocyte Common Antigens - metabolism
Leukocytes, Mononuclear - immunology
Lymphocytes
Polymorphism, Genetic - genetics
Proteins
Uganda
title CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans
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