Cytotoxic flavonoids and alpha-pyrones from Cryptocarya obovata

One alpha-pyrone, obolactone (1), two chalcones, kurzichalcolactone B (2) and obochalcolactone (3), and two flavanones, oboflavanones A (4) and B (5), have been isolated from the fruits and the trunk bark of Cryptocarya obovata. The structures of the new compounds were elucidated by spectroscopic in...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-05, Vol.67 (5), p.858-862
Main Authors: Dumontet, V, Hung, N.V, Adeline, M.T, Riche, C, Chiaroni, A, Sevenet, T, Gueritte, F
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Circular Dichroism
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Flavonoids - chemistry
Flavonoids - isolation & purification
Flavonoids - pharmacology
General pharmacology
Humans
KB Cells
Lauraceae - chemistry
Medical sciences
Molecular Conformation
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Bark - chemistry
Plants, Medicinal - chemistry
Pyrones - chemistry
Pyrones - isolation & purification
Pyrones - pharmacology
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Summary:One alpha-pyrone, obolactone (1), two chalcones, kurzichalcolactone B (2) and obochalcolactone (3), and two flavanones, oboflavanones A (4) and B (5), have been isolated from the fruits and the trunk bark of Cryptocarya obovata. The structures of the new compounds were elucidated by spectroscopic interpretations. The absolute configuration of obolactone (1) was established by circular dichroism. Obolactone (1) and obochalcolactone (3) display significant activity in in vitro cytotoxic assays against the KB cell line. Biosynthetic pathways for oboflavanones and obochalcolactone are suggested.
ISSN:0163-3864
1520-6025
DOI:10.1021/np030510h