Production of chemically pure gaseous [13N]NH3 pulses for PEP studies using a modified DeVarda reduction

A fast and reproducible production method for pure gaseous [13N]NH3 pulses has been developed. 13N was produced by irradiation of water with 500 nA of 16 MeV protons via the 16O(p,alpha)13N reaction. A mixture of DeVarda's alloy and NaOH was used to convert the produced nitrate/nitrite to ammon...

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Bibliographic Details
Published in:Applied radiation and isotopes 2002-08, Vol.57 (2), p.201-207
Main Authors: Sobczy, D P, van Grondelle, J, de Jong, A M, de Voigt, M J A, van Santen, R A
Format: Article
Language:English
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Summary:A fast and reproducible production method for pure gaseous [13N]NH3 pulses has been developed. 13N was produced by irradiation of water with 500 nA of 16 MeV protons via the 16O(p,alpha)13N reaction. A mixture of DeVarda's alloy and NaOH was used to convert the produced nitrate/nitrite to ammonia. Pre-treatment of this mixture with water increased the concentrated production of gaseous [13N]NH3. Separation and further purification of ammonia were performed with GC, leading to 5s pulses (1.1 ml STP) with 3.5 +/- 0.5 MBq [13N]NH3 with a high chemical and radiochemical purity suited for positron emission profiling (PEP).
ISSN:0969-8043
DOI:10.1016/S0969-8043(02)00094-5