Genetic predisposition to testicular germ-cell tumours

Testicular germ-cell tumours (TGCT) are the most common neoplasm in young men. Various studies have suggested the existence of an inherited predisposition to development of these tumours. Genome-wide screens subsequently provided evidence of a TGCT susceptibility gene on chromosome Xq27 ( TGCT1) tha...

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Bibliographic Details
Published in:The lancet oncology 2004-06, Vol.5 (6), p.363-371
Main Authors: Holzik, M F Lutke, Rapley, EA, Hoekstra, HJ, Sleijfer, DT, Nolte, IM, Sijmons, RH
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Biopsy, Needle
Chromosome Mapping
Genetic Predisposition to Disease
Germinoma - epidemiology
Germinoma - genetics
Germinoma - pathology
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm Staging
Pedigree
Prevalence
Prognosis
Risk Assessment
Testicular Neoplasms - epidemiology
Testicular Neoplasms - genetics
Testicular Neoplasms - pathology
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Summary:Testicular germ-cell tumours (TGCT) are the most common neoplasm in young men. Various studies have suggested the existence of an inherited predisposition to development of these tumours. Genome-wide screens subsequently provided evidence of a TGCT susceptibility gene on chromosome Xq27 ( TGCT1) that might also predispose to cryptorchism. However, this putative gene has yet to be identified, and other TGCT susceptibility genes probably exist. Completion of the human gene map and advances in genetic research will facilitate further investigation of genetic predisposition to TGCT. Insight into inheritance of TGCT might lead to the identification of individuals at increased risk of developing the disorder, increase our understanding of the mutation pathways that lead to sporadic cases, and contribute to improvement in diagnosis and treatment. Clinicians should record the family history of cancer and urogenital differentiation defects in patients with TGCT.
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(04)01493-7