Initiation of oral anticoagulant therapy in orthopedic and surgical patients: an algorithm compared with routine dosing

• Published in: European journal of clinical pharmacology 2002-06, Vol.58 (3), p.203-208
• Main Authors: van den Bemt, P M L A, Beinema, M, van Roon, E N, Sijtsma, J, Baars, W A, Mencke, H J, Brouwers, J R B J
• Format: Article
• Language: English
• Subjects: Acenocoumarol - administration & dosage; Acenocoumarol - therapeutic use; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Anticoagulants - administration & dosage; Anticoagulants - therapeutic use; Comorbidity; Female; Humans; International Normalized Ratio; Male; Middle Aged; Netherlands; Postoperative Complications - prevention & control; Venous Thrombosis - prevention & control
• ISSN: 0031-6970; 1432-1041
• DOI: 10.1007/s00228-002-0477-y

Oral anticoagulant therapy is initiated in most hospitals in The Netherlands by clinicians who routinely dose oral anticoagulants (without using an algorithm). This may explain the low proportion of patients leaving the hospital stabilized. To test this hypothesis this study compared the dosing of acenocoumarol in orthopedic and surgical patients using an algorithm with routine dosing. Because of the routine administration of low molecular weight heparin for at least the first 5 days of acenocoumarol therapy, the study focused on supratherapeutic INR-values during this period. The study included 103 patients and was performed on orthopedic surgery and general surgery wards of a Dutch hospital over 5 months. The patients received acenocoumarol as an oral anticoagulant to prevent venous thromboembolism after general of orthopedic surgery. Patients were randomized into a group routinely dosed by physicians (n=54) and a group dosed using a dosing algorithm (n=49). A patient was defined as stable if he had two consecutive INR values within the range of 2-3 during hospitalization with the first (of the two consecutive INR values within range) having been measured on day 5 or later. The groups did not differ significantly in proportion of patients stabilized, time to stabilization, or length of hospitalization. In the first period (days 1-5) the routine dosing group had significantly more INR values above therapeutic range than the algorithm group, while the algorithm group had more INR values below the therapeutic range. There were two bleeding episodes in the routine dosing group and none in the algorithm group. Despite the lack of differences in stabilization between the two groups, this study suggests an advantage of dosing acenocoumarol using an algorithm in a study population consisting of prophylactically treated, mostly elderly orthopedic patients. The algorithm provides a safe dosing schedule for elderly postoperative patients who use low molecular weight heparin and NSAIDs concomitantly and are thus at high risk for bleeding complications.