Pulling tethers from adhered vesicles

The competition between adhesion and tether formation in bound vesicles is investigated. A theoretical model is developed in which tethers are induced by the application of a pulling force to the top of a strongly adhered vesicle. A critical onset force is identified where the tether spontaneously a...

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Bibliographic Details
Published in:Physical review letters 2004-05, Vol.92 (20), p.208101-208101, Article 208101
Main Authors: Smith, Ana-Suncana, Sackmann, Erich, Seifert, Udo
Format: Article
Language:English
Subjects:
Cell Adhesion
Cytoplasmic Vesicles
Membranes
Models, Biological
Models, Theoretical
Thermodynamics
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Summary:The competition between adhesion and tether formation in bound vesicles is investigated. A theoretical model is developed in which tethers are induced by the application of a pulling force to the top of a strongly adhered vesicle. A critical onset force is identified where the tether spontaneously appears as part of a first order shape transition. Further growth of the tether initiates a detachment process that culminates in a continuous unbinding of the vesicle at a finite detachment force. Both critical forces, as well as all shape parameters, are calculated as a function of the reduced volume and the strength of adhesive potential.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.92.208101