Prediction of sun protection factors and UVA parameters of sunscreens by using a calibrated step film model

At the stage of screening of new sun protection formulations, quick and inexpensive methods for estimation of the ultraviolet (UV) screening performance are highly desirable. It has been shown recently that apart from measurements of sun protection factors in vitro, calculations using a calibrated s...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2004-07, Vol.93 (7), p.1780-1795
Main Authors: Herzog, Bernd, Mongiat, Sébastien, Quass, Katja, Deshayes, Cyrille
Format: Article
Language:English
Subjects:
Biological and medical sciences
Calibration - standards
General pharmacology
Medical sciences
Models, Biological
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
photostability
Predictive Value of Tests
step film model
sun protection factor
Sunscreening Agents - chemistry
Sunscreening Agents - radiation effects
Sunscreening Agents - standards
Ultraviolet Rays
UVA parameters
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Summary:At the stage of screening of new sun protection formulations, quick and inexpensive methods for estimation of the ultraviolet (UV) screening performance are highly desirable. It has been shown recently that apart from measurements of sun protection factors in vitro, calculations using a calibrated step film model are also a possibility. In the present investigation, further evidence for the usefulness of the step film model in terms of prediction of the sun protection factor is shown. In addition, it is demonstrated that parameters, which characterize the protection in the UVA range such as the UVA/UVB ratio and the critical wavelength can be calculated in good accordance with experimental data. Although with less accuracy, the estimation of UVA protection factors is also possible, if the photodegradation some filters undergo upon irradiation is taken into consideration. © 2004 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:1780–1795, 2004
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.20089