Loading…

Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity

We studied the association between clinical outcome in MS and allelic variants single nucleotide polymorphisms (SNPs) of interleukin-1α (IL-1α), IL-1β and a variable number tandem repeat (VNTR) in IL-1 receptor antagonist (IL-1RN). A total of 377 patients with MS were studied. Significant associatio...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroimmunology 2002-08, Vol.129 (1), p.197-204
Main Authors: Mann, C.L.A, Davies, M.B, Stevenson, V.L, Leary, S.M, Boggild, M.D, Ko Ko, C, Jones, P.W, Fryer, A.A, Strange, R.C, Thompson, A.J, Hawkins, C.P
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the association between clinical outcome in MS and allelic variants single nucleotide polymorphisms (SNPs) of interleukin-1α (IL-1α), IL-1β and a variable number tandem repeat (VNTR) in IL-1 receptor antagonist (IL-1RN). A total of 377 patients with MS were studied. Significant associations between IL-1 genotypes and clinical outcome were found using logistic regression after correction for gender, onset age and disease duration. The same trends were subsequently demonstrated in a second independent group of 67 primary progressive patients. Our results suggest that genetically determined immunomodulation mediated by IL-1 influences long-term prognosis in multiple sclerosis (MS).
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(02)00181-9