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Synthesis and Antibacterial Activity of a Novel Class of 4‘-Substituted 16-Membered Ring Macrolides Derived from Tylosin

Novel 4‘-substituted 16-membered ring macrolides were synthesized by the cleavage of the mycarose sugar of tylosin and subsequent modification of 4‘-hydroxyl group. This new class of macrolide antibiotics exhibited potent activity against some key erythromycin-resistant pathogens.

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Bibliographic Details
Published in:Journal of medicinal chemistry 2004-06, Vol.47 (12), p.2965-2968
Main Authors: Phan, Ly T, Jian, Tianying, Chen, Zhigang, Qiu, Yao-Ling, Wang, Zhaolin, Beach, Theresa, Polemeropoulos, Alex, Or, Yat Sun
Format: Article
Language:English
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Summary:Novel 4‘-substituted 16-membered ring macrolides were synthesized by the cleavage of the mycarose sugar of tylosin and subsequent modification of 4‘-hydroxyl group. This new class of macrolide antibiotics exhibited potent activity against some key erythromycin-resistant pathogens.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm034233n