Defining Tympanostomy Tube Plugs

Objectives To define the composition of tympanostomy tube plugs because selecting or developing effective solvents depends on such knowledge. Study Design Prospective, in vitro laboratory study. Methods Luminal contents of 105 plugged, microscopically removed tympanostomy tubes were expressed, poole...

Full description

Saved in:
Bibliographic Details
Published in:The Laryngoscope 2002-06, Vol.112 (6), p.951-954
Main Authors: Westine, John G., Giannoni, Carla M., Antonelli, Patrick J.
Format: Article
Language:English
Subjects:
Amino Acids - analysis
Biological and medical sciences
Chromatography, High Pressure Liquid
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
Humans
Medical sciences
middle ear effusion
Middle Ear Ventilation
Monosaccharides - analysis
mucoid
Mucus - chemistry
Non tumoral diseases
Otitis Media with Effusion - metabolism
Otorhinolaryngology. Stomatology
Prospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the ear, the auditive nerve and the facial nerve
Tympanostomy tube
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To define the composition of tympanostomy tube plugs because selecting or developing effective solvents depends on such knowledge. Study Design Prospective, in vitro laboratory study. Methods Luminal contents of 105 plugged, microscopically removed tympanostomy tubes were expressed, pooled, acid hydrolyzed, and passed through a high‐performance liquid chromatography column. Retention times were compared with high‐performance liquid chromatography standards to develop free amino acid and monosaccharide profiles. Cerumen, blood, and chronic mucoid effusion (collected during myringotomy) were pooled and subjected to the same analysis. The elution profiles of each substance were compared to determine which substance most closely matched the plugs. Results High‐performance liquid chromatography amino acid and monosaccharide analysis demonstrated greatest similarity between tympanostomy tube plugs and mucoid effusion. Conclusions Tympanostomy tube plug composition is more similar to mucoid effusion than to blood or cerumen. Solvents to open plugged tympanostomy tubes should be directed against the components of mucoid effusion.
ISSN:0023-852X
1531-4995
DOI:10.1097/00005537-200206000-00003