Cross-reactivity of cefotetan and ceftriaxone antibodies, associated with hemolytic anemia, with other cephalosporins and penicillin

Most drug-induced immune hemolytic anemias since the late 1980s have been caused by the second- and third-generation cephalosporins, cefotetan and ceftriaxone, respectively. Cross-reactivity of cefotetan and ceftriaxone antibodies with other cephalosporins or penicillin has been studied only minimal...

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Bibliographic Details
Published in:American journal of clinical pathology 2002-08, Vol.118 (2), p.256-262
Main Authors: ARNDT, Patricia A, GARRATTY, George
Format: Article
Language:English
Subjects:
Anemia, Hemolytic - immunology
Antibodies - immunology
Biological and medical sciences
Cefamandole - immunology
Cefoperazone - immunology
Cefotaxime - immunology
Cefotetan - immunology
Cefoxitin - immunology
Ceftriaxone - immunology
Cells, Cultured
Cephalosporins - immunology
Cephalothin - immunology
Cross Reactions
Drug toxicity and drugs side effects treatment
Humans
Medical sciences
Models, Chemical
Penicillins - immunology
Pharmacology. Drug treatments
Toxicity: blood
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Summary:Most drug-induced immune hemolytic anemias since the late 1980s have been caused by the second- and third-generation cephalosporins, cefotetan and ceftriaxone, respectively. Cross-reactivity of cefotetan and ceftriaxone antibodies with other cephalosporins or penicillin has been studied only minimally. We tested 7 serum samples previously identified to contain cefotetan antibodies and one serum sample previously identified to contain ceftriaxone antibodies against 9 other cephalosporins, penicillin, and 7-aminocephalosporanic acid in the presence of RBCs and also used hapten inhibition to indicate cross-reactivity. Serum samples containing cefotetan antibodies showed some cross-reactivity with cephalothin and cefoxitin (and to a much lesser extent with penicillin and ceftazidime). The ceftriaxone antibodies showed very weak cross-reactivity with cefotaxime, cefamandole, and cefoperazone. There was very little cross-reactivity between cefotetan antibodies and the drugs tested in the present study. We have no data to determine whether the in vitro data relate to in vivo reactivity.
ISSN:0002-9173
1943-7722
DOI:10.1309/JFJE-VUKN-221T-G6EV