IL-6 AND LIPOPROTEIN (a) [LP(a)] CONCENTRATIONS ARE RELATED ONLY IN PATIENTS WITH HIGH APO(a) ISOFORMS IN MONOCLONAL GAMMOPATHY

We have investigated the influence of apo(a) genetics on the relationship between interleukin (IL)-6, and lipoprotein (a) [Lp(a)] levels in 154 patients with monoclonal gammopathy and 189 healthy subjects. No significant differences in Lp(a) levels and distribution of subjects with different sizes o...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2002-06, Vol.18 (6), p.340-343
Main Authors: Horváth, Laura, Császár, Albert, Falus, András, Dieplinger, Hans, Horváth, Anna, Puskás, Éva, Halm, Gabriella, Bányai, Anikó, Pálóczi, Katalin, László, Elöd, Kalabay, László, Romics, László, Füst, George
Format: Article
Language:English
Subjects:
Adult
Aged
apolipoprotein(a)/IL-6/lipoprotein(a)/Lp(a)/multiple myeloma
Apolipoproteins A - biosynthesis
Apolipoproteins A - chemistry
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interleukin-6 - biosynthesis
Interleukin-6 - blood
Lipoprotein(a) - biosynthesis
Male
Middle Aged
Multiple Myeloma - metabolism
Paraproteinemias - metabolism
Polymorphism, Genetic
Protein Isoforms
Waldenstrom Macroglobulinemia - metabolism
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Summary:We have investigated the influence of apo(a) genetics on the relationship between interleukin (IL)-6, and lipoprotein (a) [Lp(a)] levels in 154 patients with monoclonal gammopathy and 189 healthy subjects. No significant differences in Lp(a) levels and distribution of subjects with different sizes of apo(a) isoforms were found between patients and healthy controls. Relationship between IL-6 and Lp(a) levels was strongly dependent on the size of apo(a) isoforms. In patients with high-size apo(a) isoforms Lp(a) levels positively correlated (r=0.475, P=0.0007) to IL-6 concentrations, whereas no correlation was found in patients with low apo(a) isoforms. Our present finding may provide a plausible explanation for the contradictory findings about the acute phase protein nature of Lp(a).
ISSN:1043-4666
1096-0023
DOI:10.1006/cyto.2002.1044