Rho Family GTPases as Key Regulators for Neuronal Network Formation

Rho family GTPases act as transducers of signals from extracellular stimuli to the cytoskeleton and gene expression. Their actions are temporal and spatial determinants for cellular functions. The cellular functions of Rho family GTPases have been studied in fibroblasts and endothelial cells, and re...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 2002-08, Vol.132 (2), p.157-166
Main Authors: Negishi, Manabu, Katoh, Hironori
Format: Article
Language:English
Subjects:
Animals
Cell Line
Cell Movement - physiology
Cell Size
G protein
Humans
Nerve Growth Factors - metabolism
Nerve Net - physiology
Nervous System Diseases - genetics
Nervous System Diseases - metabolism
neuron
neuronal network
Neurons - cytology
Neurons - metabolism
Phylogeny
Rho
rho GTP-Binding Proteins - classification
rho GTP-Binding Proteins - genetics
rho GTP-Binding Proteins - metabolism
Signal Transduction - physiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rho family GTPases act as transducers of signals from extracellular stimuli to the cytoskeleton and gene expression. Their actions are temporal and spatial determinants for cellular functions. The cellular functions of Rho family GTPases have been studied in fibroblasts and endothelial cells, and recent advances have revealed their roles in the regulation of neuronal network formation, including migration, neurite outgrowth, polarity, axon guidance, dendrite maturation and synapse formation. In addition, a significant number of X-linked mental retardation genes have been shown to encode components directly involved in signal transduction pathways of Rho family GTPases, underscoring the view that Rho family GTPases essentially participate in the neuronal network formation. In this review, we will overview current understanding of the functions of Rho family GTPases in neuronal network formation.
ISSN:0021-924X
DOI:10.1093/oxfordjournals.jbchem.a003205