Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)

Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw e...

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Bibliographic Details
Published in:Journal of neuroimmunology 2002-08, Vol.129 (1), p.35-42
Main Authors: Dimitrijević, Mirjana, Stanojević, Stanislava, Vujić, Vesna, Kovačević-Jovanović, Vesna, Beck-Sickinger, Annette, Demuth, Hans-Ulrich, Hörsten, Stephan von
Format: Article
Language:English
Subjects:
Animals
Arginine - analogs & derivatives
Arginine - pharmacology
Cells, Cultured
Concanavalin A - pharmacology
Dipeptidyl Peptidase 4 - drug effects
Dipeptidyl Peptidase 4 - immunology
Dipeptidyl-peptidase IV (DPIV, CD26)
Dose-Response Relationship, Drug
Edema - chemically induced
Edema - enzymology
Edema - immunology
Hydrogen Peroxide - immunology
Hydrogen Peroxide - metabolism
Inflammation
Inflammation - chemically induced
Inflammation - enzymology
Inflammation - immunology
Isoleucine - analogs & derivatives
Isoleucine - pharmacology
Macrophages - drug effects
Macrophages - immunology
Macrophages - metabolism
Male
Neuropeptide Y (NPY)
Neuropeptide Y - analogs & derivatives
Neuropeptide Y - immunology
Neuropeptide Y - pharmacology
NPY receptors
Paw edema
Peptide Fragments - pharmacology
Peptide YY - pharmacology
Rats
Rats, Wistar
Receptors, Neuropeptide Y - agonists
Receptors, Neuropeptide Y - antagonists & inhibitors
Receptors, Neuropeptide Y - immunology
Thiazoles - pharmacology
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Summary:Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(02)00173-X